In 2013 she played the title character in the series Susanna.She also guest starred as Faith in Californication.

Variety reported in May 2005 that Grace was in negotiations to play X-Men character Kitty Pryde in the 2006 film X-Men: The Last Stand, but in July, auditions were reportedly being held for her replacement.

The role ultimately went to Ellen Page, and Grace later revealed that she had never been contacted about the role and was surprised to read that she was up for the part in question.

She attended Worthington Christian Schools from kindergarten through ninth grade and briefly attended Thomas Worthington High School, where she began acting in school plays and community theater, including a Jewish Community Center's Gallery Players' 2000 production of The Crucible.

Her parents divorced "amicably" when she was 16 years old, but her mother sought a "fresh start".

She was nominated for a Young Artist Award for her portrayal of Moxley in the Best Performance in a TV Movie, Miniseries or Special – Leading Young Actress category, but lost to Clara Bryant for Tru Confessions.

She went on to feature in minor roles on the television series CSI: Miami, The Lyon's Den, Miracles, Like Family, Cold Case and Law & Order: Special Victims Unit, and the films Twelve Mile Road and Creature Unknown, before appearing in a season-long recurring role on Oliver Beene as a Swedish exchange student.

She lived in Hawaii during the filming of the show's first season, and signed on to star opposite Tom Welling in The Fog, a 2005 remake of the 1980 horror film of the same name, as a character originally played by Jamie Lee Curtis.

Though the filming of Lost was supposed to have ended before The Fog began, the productions coincided due to Lost's extended season finale and Grace flew between the two sets, on Hawaiian the island of Oahu and on Bowen Island in British Columbia, Canada.

Grace dropped out of high school to move to Los Angeles, California with her mother, while her younger siblings Ian and Marissa continued to live with their father.