In 18, the canuts (silk workers) of Lyon staged two major uprisings for better working conditions and pay.

Burgundian refugees fleeing the destruction of Worms by the Huns in 437 were re-settled by the military commander of the west, Aëtius, at Lugdunum.

This became the capital of the new Burgundian kingdom in 461.

Jean-Marie Collot d'Herbois and Joseph Fouché administered the execution of more than 2,000 people.

After Lyons was defeated in October of 1793, the Convention ordered that its name be changed to "Liberated City." A plaque was also erected which proclaimed" "Lyons made war on Liberty; Lyons no longer exists." A decade later, Napoleon ordered the reconstruction of all the buildings demolished during this period.

In 843, by the Treaty of Verdun, Lyon, with the country beyond the Saône, went to Lothair I. Lyon did not come under French control until the 14th century.

Fernand Braudel remarked, "Historians of Lyon are not sufficiently aware of the bi-polarity between Paris and Lyon, which is a constant structure in French development..the late Middle Ages to the Industrial Revolution".

Today, the archbishop of Lyon is still referred to as "Primat des Gaules" and the city often referred to as the "capitale des Gaules".

The Christians in Lyon were martyred for their beliefs under the reigns of various Roman emperors, most notably Marcus Aurelius and Septimus Severus.

According to the historian Dio Cassius, in 43 BC, the Roman Senate ordered Munatius Plancus and Lepidus, lieutenants of the assassinated Julius Caesar and governors of central and Transalpine Gaul, respectively, to found a settlement for a group of Roman refugees.