Prostate cancer is the most common noncutaneous cancer in men.Although prostate cancer can be a slow-growing cancer, thousands of men die of the disease each year.

It is surrounded by a capsule and is separated from the rectum by a layer of fascia termed the Denonvilliers aponeurosis.

(See the image below.) The inferior vesical artery, which is derived from the internal iliac artery, supplies blood to the base of the bladder and prostate.

Prostate cancer is the most common noncutaneous cancer in men in the United States.

An estimated one in six white men and one in five African-American men will be diagnosed with prostate cancer in their lifetime, with the likelihood increasing with age.

A draft guideline from the US Preventive Services Task Force (USPSTF), issued in April 2017, advises that in men aged 55 to 69 years, the decision of whether or not to undergo screening should be individualized.

For men aged 70 years and older, the USPSTF recommends against PSA-based screening for prostate cancer.

Currently, the majority of prostate cancers are identified in patients who are asymptomatic.

Diagnosis in such cases is based on abnormalities in a screening prostate-specific antigen (PSA) level or findings on digital rectal examination (see Presentation and Workup).

Physical examination alone cannot reliably differentiate benign prostatic disease from cancer.